Paracrine Action of Bone Morphogenetic Protein 3 in Pulmonary Arterial Hypertension

20251 citationsPreprintgreen Open Access

Authors

Aymen Halouani · Biomedical Research Institute

Eric Mensiah · Biomedical Research Institute

Zaujia Athumani · Biomedical Research Institute

Michael G. Katz · Icahn School of Medicine at Mount Sinai

Krzysztof Jankowski · Icahn School of Medicine at Mount Sinai

Mohd Nizam Mansoori · Icahn School of Medicine at Mount Sinai

Vicki Rosen

Abstract

Our findings provide evidence that BMP3 overexpression attenuates pulmonary vascular remodeling and inhibits cardiac dysfunction by restoring the balance between the TGF-β and BMP pathways through a cell-cell communication mechanism, offering a novel therapeutic pathway for PAH.

Topics & Keywords

Pulmonary Hypertension Research and Treatments Medical Imaging and Pathology Studies Bone health and treatments

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2025.06.13.659638

Command Palette

Paracrine Action of Bone Morphogenetic Protein 3 in Pulmonary Arterial Hypertension

Authors

Abstract

Topics & Keywords

Publication Details