6P Organoid models reveal endometrial cancer microenvironment and drug resistance

20250 citationsJournal Articlegold Open Access

Authors

Salvatore Vaccarella · National Cancer Institute

Vincenzo Bruno · Istituti di Ricovero e Cura a Carattere Scientifico

G Orlandi · San Gallicano Hospital

D. Covino · San Gallicano Hospital

Carlotta Frascolla · National Cancer Institute

Claudio Pulito · National Cancer Institute

R. Vizza

Abstract

Endometrial cancer (EC) is the most common gynaecologic cancers among women worldwide. Currently, the gold standard for EC treatment is surgery, radiation and chemotherapy. Tumor microenvironment (TME), specifically Cancer-Associated Fibroblasts (CAFs), is an important promoter of tumor development affecting proliferation, immune evasion, relapse and migration. Patient-derived organoids (PDOs), 3D preclinical models, are emerging as promising tools for evaluating novel therapeutic strategies for promoting personalized therapies.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: ESMO Open

Volume 10, pp. 105135-105135

DOI: 10.1016/j.esmoop.2025.105135

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