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In this special issue of the Politics and Religion Journal we are pleased to present a collection of scholarly research on the Organization of Islamic Cooperation (OIC).As a major intergovernmental organization, the OIC has profoundly influenced political, social, and economic discourse both within the Muslim world and globally.This issue provides a comprehensive examination of the OIC's historical evolution, key decisions, reforms, and ongoing challenges.The OIC has also in recent years assumed a more dynamic role in global diplomacy, marked by notable shifts in its strategies and priorities.It has heightened its efforts in combating Islamophobia, advancing human rights, and promoting sustainable development, alongside fostering interfaith dialogue.Among its achievements are initiatives aimed at addressing religious discrimination and advocating for Muslim minorities on the international stagvve, which have strengthened its influence within the United Nations and other global forums.However, the OIC still faces complex challenges, necessitating its adaptation to rapidly evolving economic and geopolitical realities.This issue offers a series of in-depth analyses on various dimensions of the OIC's role and influence.Among the topics explored are the historical evolution of the OIC, as detailed in From Historical Caliphate to Modern Governance Alliance, its efforts to counter religious defamation and Islamophobia, the Palestinian question, the advancement of women, the plight of displaced women, the OIC's use of soft power, Waqf development, and the safeguarding of minority rights.Mahmoud Alrantisi examines the evolving stance of the OIC on the Palestinian issue, particularly in light of the recent Israeli aggression since October 7, 2023.Recognized as the principal international entity representing Islamic nations, the OIC's role is crucial in addressing this significant concern for Islamic communities.The study highlights the OIC's achievements and challenges in supporting Palestinian 1