B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

20255 citationsJournal Articlehybrid Open Access

Authors

Sanya Mehta · St. Jude Children's Research Hospital

Siri Ippagunta · St. Jude Children's Research Hospital

Srinidhi Varadharajan · St. Jude Children's Research Hospital

Alisha Kardian · St. Jude Children's Research Hospital

Nic Laboe · St. Jude Children's Research Hospital

Diana Dinh · St. Jude Children's Research Hospital

Amber B. Jones

Abstract

Our results support ongoing clinical evaluation of B7-H3.CAR T cells for ependymomas and provide model systems for further studying determinants of anti-ependymoma CAR T-cell treatment efficacy and resistance.

Topics & Keywords

CAR-T cell therapy research Silicon Carbide Semiconductor Technologies Advancements in Semiconductor Devices and Circuit Design

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 31, Issue 17, pp. 3754-3770

DOI: 10.1158/1078-0432.ccr-24-3083

Field-Weighted Citation Impact: 5.20