Biodistribution of free Francium-221 and Bismuth-213 in Tumour-bearing SCID mice after successful development of Actinium-225/Francium-221 radionuclide generator Set-up

We present an unprecedented concept utilizing LN2 resin in ²²⁵Ac/²²¹Fr generator applications. Successfully eluted and injected ²²¹Fr fractions showed strong accumulation of ²²¹Fr and ²¹³Bi in key organs. Our data provide preliminary evidence of the potential contribution of recoiled progeny radionuclides to side-effects in non-targeted organs.