Gut microbiome compositional and functional features associate with Alzheimer's disease pathology

20259 citationsJournal Articlehybrid Open Access

Authors

Jea Woo Kang · University of Wisconsin–Madison

Lora Khatib · University of California, San Diego

Margo B. Heston · University of Wisconsin–Madison

Amanda Hazel Dilmore · University of California, San Diego

Jennifer S. Labus · Center for Neurologic Study

Yuetiva Deming · University of Wisconsin–Madison

Leyla Schimmel

Abstract

Gut microbiome composition and function differ between people with Alzheimer's disease (AD) dementia and cognitively unimpaired (CU) individuals. Co-occurring gut microbes show differential abundance across AD-related groups (AD vs CU, amyloid status+ vs amyloid status-, and apolipoprotein E (APOE) ε4 status+ vs APOE ε4 status-). Gut microbiome composition also differs between people with AD dementia and CU individuals in a larger validation cohort. Differentially abundant gut microbiome composition and function between AD and CU groups are correlated with cerebrospinal fluid biomarkers for AD and related pathologies.

Topics & Keywords

Gut microbiota and health Diet and metabolism studies Tryptophan and brain disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia

Volume 21, Issue 7, pp. e70417-e70417

DOI: 10.1002/alz.70417

Field-Weighted Citation Impact: 7.72