Immunomodulatory effects of atorvastatin on peripheral blood mononuclear cells infected with Mycobacterium tuberculosis

20254 citationsJournal Articlegold Open Access

Authors

Solima Sabeel · International Centre for Genetic Engineering and Biotechnology

Bongani Motaung · International Centre for Genetic Engineering and Biotechnology

Mumin Ozturk · University of Cape Town

Trevor S Mafu · Wellcome Centre for Infectious Diseases Research in Africa

Robert J. Wilkinson · Imperial College London

Friedrich Thienemann · University Hospital of Zurich

Reto Guler

Abstract

Our findings highlight atorvastatin's potential as a crucial modulator of the immune response in <i>Mtb</i>-infected PBMCs, supporting its role in host-directed therapy.

Topics & Keywords

Tuberculosis Research and Epidemiology Infectious Diseases and Tuberculosis interferon and immune responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Immunology

Volume 16, pp. 1597534-1597534

DOI: 10.3389/fimmu.2025.1597534

Field-Weighted Citation Impact: 5.86