Phase Ib Study of Pembrolizumab in Combination with Intratumoral Injection of <i>Clostridium novyi</i> -NT in Patients with Advanced Solid Tumors

20253 citationsJournal Articlehybrid Open Access

Authors

Blessie Elizabeth Nelson · The University of Texas MD Anderson Cancer Center

Filip Jankú · The University of Texas MD Anderson Cancer Center

Siqing Fu · The University of Texas MD Anderson Cancer Center

Ecaterina E. Dumbrava · The University of Texas MD Anderson Cancer Center

David S. Hong · The University of Texas MD Anderson Cancer Center

Daniel D. Karp · The University of Texas MD Anderson Cancer Center

Abstract

This study highlights the potential of the C. novyi-NT and pembrolizumab combination as a promising therapeutic strategy for treatment-refractory solid tumors.

Topics & Keywords

Cancer Research and Treatments Clostridium difficile and Clostridium perfringens research Pancreatic and Hepatic Oncology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 31, Issue 18, pp. 3864-3875

DOI: 10.1158/1078-0432.ccr-24-3952

Field-Weighted Citation Impact: 3.70