Global Characterization of Genetic Variation by Using High-Throughput Technologies

Genetic variation, variation in alleles of genomes, occurs bith within and among populations and individuals. Genetic variation is important because it provides the "raw material" for evolution. Discovery of vatiants that determine phenotypes became a fundamental premise of genetic research. This projekt aimed to characterize large scale of genetic vaiations in complex genomes by applying hig-throughput technologies and bioinformatic approache4s, to help investigate genetic foundation of disease susceptibility and product traits in livestock species. This PhD project provide a comprehensive sight into genetic variation in bovine and swine genomes and relevant methodologies; valuable resources such as novel genome sequences of pathogens, genome annotations and genetic variations were produced for research communities regard to animal health and welfare in animal breeding industriy