Functional humanization of 15-lipoxygenase-1 (Alox15) protects mice from dextran sodium sulfate induced intestinal inflammation

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Authors

Florian Reisch · University of Potsdam

Marjann Schäfer · University of Potsdam

Dominika Łabuz · Humboldt-Universität zu Berlin

Halina Machelska · Humboldt-Universität zu Berlin

Sabine Stehling · Humboldt-Universität zu Berlin

Gerhard P. Püschel · University of Potsdam

Michael Rothe ·

Abstract

Taken together, our data suggest that humanization of the reaction specificity of mouse Alox15 (Leu353Phe mutation) exhibits differential effects in two mouse inflammation models.

Topics & Keywords

Asthma and respiratory diseases Inflammatory mediators and NSAID effects Estrogen and related hormone effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cellular & Molecular Biology Letters

Volume 30, Issue 1, pp. 81-81

DOI: 10.1186/s11658-025-00756-0

Field-Weighted Citation Impact: 1.14