Brain and CSF Alzheimer’s Biomarkers Are Associated with SERPINE1 Gene Expression

20250 citationsJournal Articlegold Open Access

Authors

Cynthia Picard · Douglas Mental Health University Institute

Henrik Zetterberg · Sahlgrenska University Hospital

Kaj Blennow · Sahlgrenska University Hospital

Sylvia Villeneuve · Center for Diagnosis and Research on Alzheimer's Disease

Judes Poirier · Douglas Mental Health University Institute

Abstract

CSF SERPINE1 levels can be used as an early biomarker for the detection of pathological changes associated with AD. Higher SERPINE1 levels correlate more strongly with tau pathology than with amyloid formation or deposition.

Topics & Keywords

Alzheimer's disease research and treatments S100 Proteins and Annexins Dementia and Cognitive Impairment Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genes

Volume 16, Issue 7, pp. 818-818

DOI: 10.3390/genes16070818

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