Language impairment is associated with faster progression in progressive supranuclear palsy‐Richardson syndrome

20251 citationsJournal Articlehybrid Open Access

Authors

Indira García‐Cordero · University of Toronto

Juan‐Camilo Vargas‐González · Occupational Cancer Research Centre

Mohsen Hadian · University of Toronto

Ece Bayram · University of Colorado Anschutz Medical Campus

Federico Rodríguez‐Porcel · Medical University of South Carolina

Blas Couto · Favaloro University

Jay M. Iyer

Abstract

Speech and language deficits predict a worse prognosis in progressive supranuclear palsy-Richardson syndrome (PSP-RS). Lower language scores are associated with worse cognitive performance over time. Lower language scores related to higher neurofilament-light chain (NfL) at baseline. The low language-score group presented greater atrophy in language-related brain areas. Stratifying PSP-RS cases using language scores may improve clinical trials.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Alzheimer's disease research and treatments

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Alzheimer s & Dementia

Volume 21, Issue 7, pp. e70485-e70485

DOI: 10.1002/alz.70485

Field-Weighted Citation Impact: 1.45