Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates

20250 citationsJournal Articlegold Open Access

Authors

Pierre Gaudeaux · Institut des Maladies Génétiques Imagine

Juliette Paillet · Smartesting (France)

Monah Abou Alezz · The San Raffaele Telethon Institute for Gene Therapy

Ranjita Devi Moirangthem · Université Paris Cité

Sara Cascione · The San Raffaele Telethon Institute for Gene Therapy

Marta Martin Corredera · Institut des Maladies Génétiques Imagine

Anne‐Catherine Dolens

Abstract

These findings underscore the versatility of DLL4-based lymphoid progenitors in generating either T cells or ILCs in response to environmental cues. This research paves the way for innovative cell therapy approaches to treat immune deficiencies and cancer- and age-related immune dysfunctions.

Topics & Keywords

IL-33, ST2, and ILC Pathways Immune Cell Function and Interaction CAR-T cell therapy research

Publication Details

Published in: Frontiers in Immunology

Volume 16, pp. 1617707-1617707

DOI: 10.3389/fimmu.2025.1617707

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Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates

Authors

Abstract

Topics & Keywords

Publication Details