Fluctuations in copy number of the class A carbapenemase gene <i>bla</i>FRI appear to confer high-level carbapenem resistance

20250 citationsJournal Article

Authors

Makiko Noda · Gunma Prefectural Institute of Public Health and Environmental Sciences

Ayako Furuta · Gunma Prefectural Institute of Public Health and Environmental Sciences

Shigeko Yashima · Gifu Prefectural Tajimi Hospital

Daizo Yaguchi · Gifu Prefectural Tajimi Hospital

Yoshihiko Kameyama · Gifu Prefectural Research Institute for Fisheries and Aquatic Environments

Yuba Inamine · National Institute of Infectious Diseases

Abstract

The high-level carbapenem resistance in this clinical isolate was attributed to multiple duplications of FRI9-LR. Furthermore, the flexibility in the duplication of this region resulted in changes in antimicrobial susceptibility, without loss or acquisition of resistance genes.

Topics & Keywords

Antibiotic Resistance in Bacteria Bacterial Identification and Susceptibility Testing Infections and bacterial resistance

Publication Details

Published in: Journal of Antimicrobial Chemotherapy

Volume 80, Issue 9, pp. 2503-2512

DOI: 10.1093/jac/dkaf258

Field-Weighted Citation Impact: 0.00

Command Palette

Fluctuations in copy number of the class A carbapenemase gene <i>bla</i>FRI appear to confer high-level carbapenem resistance

Authors

Abstract

Topics & Keywords

Publication Details