A multivariate cell-based liquid biopsy for lung nodule risk stratification: Analytical validation and early clinical evaluation

This study establishes the analytical reproducibility and biological relevance of the LC-iCAP. While clinical validation is preliminary, the results support the assay's potential utility in lung nodule management. The study introduces a new paradigm of using scalable and cost-effective cell-based biosensor assays for liquid biopsies. With a multivariate readout, the platform is amenable to precision medicine applications such as multi-cancer early detection.