Diagnosing Wilson Disease in Acute Liver Failure: Comparison of Existing and Experimental Biomarkers

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Authors

Thomas Damgaard Sandahl · Aarhus University Hospital

Chris F. Harrington · Supra-Regional Assay Service

Frederik Teicher Kirk · Aarhus University Hospital

Gurth Carpenter · Supra-Regional Assay Service

Leisa Douglas · Supra-Regional Assay Service

Craig N. Mills · Supra-Regional Assay Service

Jody A. Rule

Abstract

Standard biochemistry provides excellent diagnostic information for identifying WD in the setting of ALF. Combining ALT with specific copper measurements significantly improved diagnostic use, with ANCC outperforming s-Cu. RelANCC may also be useful for WD diagnosis. We suggest adding s-Cu to the clinical algorithm in ALF.

Topics & Keywords

Trace Elements in Health Drug Transport and Resistance Mechanisms Metabolism and Genetic Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The American Journal of Gastroenterology

DOI: 10.14309/ajg.0000000000003654

Field-Weighted Citation Impact: 1.12