Genetic alterations affect immune contexture of non-small cell lung cancer: Ukrainian study

The high rate of PD-L1 expression in NSCLC driven by <i>EGFR</i> and <i>ALK</i> alterations was accompanied by a prevalence of low immunogenicity with a shift toward ID TME in <i>EGFR</i> mutant tumors and IE TME in <i>ALK-</i>rearranged and <i>KRAS</i> mutant NSCLC. Further discovery of mechanisms affecting tumor immune contexture is needed for tailoring patient management in line with particular mechanisms of immune evasion.