Ophthalmological Question Answering and Reasoning Using OpenAI o1 vs Other Large Language Models

This study found that o1 excelled in accuracy but showed inconsistencies in text-generation metrics, trailing GPT-4o and GPT-4; expert reviews found o1's responses to be more clinically useful and better organized than GPT-4o. While o1 demonstrated promise, its performance in addressing ophthalmology-specific challenges is not fully optimal, underscoring the potential need for domain-specialized LLMs and targeted evaluations.