Suppressing SMURF1 to preserve GSTM2: An approach to reducing gastric cancer aggressiveness in vitro and in vivo.

20260 citationsJournal Article

Authors

Yuanting Lu · Tangshan People's Hospital

Abstract

This study reveals a novel oncogenic axis, where SMURF1 promotes gastric cancer progression by targeting GSTM2 for degradation. Inhibiting SMURF1 stabilizes GSTM2, leading to reduced cell proliferation, migration, and invasion both in vitro and in vivo.

Topics & Keywords

Glutathione Transferases and Polymorphisms Computational Drug Discovery Methods Enzyme function and inhibition

Publication Details

Published in: PubMed

Volume 41, Issue 3, pp. 505-516

DOI: 10.14670/hh-18-974

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Suppressing SMURF1 to preserve GSTM2: An approach to reducing gastric cancer aggressiveness <i>in vitro</i> and <i>in vivo</i>.

Authors

Abstract

Topics & Keywords

Publication Details