xShare-Powered Personal Digital Twins: End of Privacy or Key to Precision Health?

The proliferation of health data available in real-time and the availability of low-cost computation are powering a new research area: Digital Twins. In the context of the European Health Data Space (EHDS), an enabler for personal Digital Twins is the xShare "Yellow" Button that aims to empower individuals to share their data, one time, or for a period with applications of their choice. This paper presents different use cases that are made possible by the personal health twins and reflects on relevant challenges and opportunities, debating whether ethical and privacy concerns can overcome the benefits of personalized precision medicine powered with the dynamic real-time feedback to digital twins.