Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

20253 citationsJournal Articlegreen Open Access

Authors

Jianpeng Yu · Duke University

Chen Jin · Duke University

Cheng Su · Duke University

David Moon · Duke University

Michael A. Sun · Duke University

Hong Zhang · Duke University

Xue Jiang · Duke University

Abstract

Together, these findings reveal purinosome assembly and purine salvage as key mechanisms of cancer cell adaptation and resilience to purine shortage while identifying microtubules, MTAP, and immunoevasion deficits as therapeutic vulnerabilities.

Topics & Keywords

Adenosine and Purinergic Signaling Cancer-related Molecular Pathways Autophagy in Disease and Therapy

Publication Details

Published in: Clinical Cancer Research

Volume 31, Issue 20, pp. 4345-4360

DOI: 10.1158/1078-0432.ccr-25-1667

Field-Weighted Citation Impact: 3.29

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Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

Authors

Abstract

Topics & Keywords

Publication Details