Dual targeting of conserved cell cycle and transcription programs in advanced colorectal cancer by fadraciclib

20250 citationsJournal Articlegold Open Access

Authors

Mohammad Zokaasadi · Duke University

Wylie K. Watlington · Duke University

Divya L. Dayanidhi · Duke University

John B. Mantyh · Duke University

Gabrielle Rupprecht · Duke University

Shannon J. McCall · Duke University

David Blake ·

Abstract

Our results using patient-derived models suggest that fadraciclib is a promising therapy for advanced CRC by inhibiting CDKs 2 and 9, which affects critical pathways in cell cycle regulation and transcription.

Topics & Keywords

Advanced Breast Cancer Therapies Cancer therapeutics and mechanisms Cancer Mechanisms and Therapy

Publication Details

Published in: Evolution Medicine and Public Health

Volume 13, Issue 1, pp. 281-290

DOI: 10.1093/emph/eoaf021

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Dual targeting of conserved cell cycle and transcription programs in advanced colorectal cancer by fadraciclib

Authors

Abstract

Topics & Keywords

Publication Details