Glymphatic activity in behavioral variant frontotemporal dementia: Link with vascular function and astrocytic activation

Our findings reveal a complex interrelationship among glymphatic, vascular, and inflammatory mechanisms in FTD, highlighting their collective impact on disease severity. Highlight Vascular function, astrocytic activation, and glymphatic activity correlate with each other in frontotemporal dementia. Glymphatic activity mediates the association between vascular function and cognition. Astrocytic activation mediates the association between glymphatic function and cognition. Vascular and glymphatic function synergy drives white matter hyperintensity.