Injectable-Only Overlapping Buprenorphine Starting Protocol in a Low-Threshold Setting

This retrospective cohort study found that a novel injectable-only overlapping buprenorphine starting protocol had a relatively high rate of completion and 2-month retention in a low-threshold setting for individuals with OUD who used fentanyl, most of whom were experiencing homelessness. These findings suggest that this protocol is a promising potential pathway for patients to start buprenorphine in the outpatient setting.