Longitudinal Autoantibody and Proteomic Signatures of Disease Progression in Systemic Sclerosis

20250 citationsJournal Articlebronze Open Access

Authors

Muyao Guo · Central South University

Sijia Liu · Central South University

Jing Huang · Central South University

Ying Long · Central South University

Wei Yu · Central South University

Quan‐Zhen Li · Central South University

Hui Luo ·

Abstract

Dynamic changes in autoantibody titers, rather than baseline levels, were more strongly associated with SSc trajectory. Proteomic signatures suggest lipid metabolism and oxidative stress as potential drivers, highlighting novel biomarkers and therapeutic targets for personalized SSc management.

Topics & Keywords

Systemic Sclerosis and Related Diseases Inflammatory Myopathies and Dermatomyositis Celiac Disease Research and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis & Rheumatology

Volume 78, Issue 2, pp. 394-402

DOI: 10.1002/art.43354

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