Prevalence, Severity, and Progression of Cerebellar Cognitive-Affective Syndrome in Patients With Spinocerebellar Ataxias

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Authors

Emilien Petit · Centre National de la Recherche Scientifique

Daniel López Domínguez · Centre National de la Recherche Scientifique

Cécilia Marelli · Inserm

Sabrina Sayah · Centre National de la Recherche Scientifique

Stefan M. Pulst · University of Utah

Jennifer Faber · University Hospital Bonn

Gülin Öz

Abstract

We observed early cognitive impairment in PolyQ SCA carriers, correlating with clinical measures, NfL levels, and cerebellum volume. Improvement over 3 years likely reflects a practice effect, potentially limiting the scale's longitudinal utility.

Topics & Keywords

Genetic Neurodegenerative Diseases Mitochondrial Function and Pathology Neurological disorders and treatments

Publication Details

Published in: Neurology

Volume 105, Issue 5, pp. e213980-e213980

DOI: 10.1212/wnl.0000000000213980

Field-Weighted Citation Impact: 1.82

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Prevalence, Severity, and Progression of Cerebellar Cognitive-Affective Syndrome in Patients With Spinocerebellar Ataxias

Authors

Abstract

Topics & Keywords

Publication Details