COVID-19 vaccine induced subacute cutaneous lupus erythematosus

It has been documented that COVID-19 vaccinations have been associated with the exacerbation of underlying autoimmune conditions as well as the new onset development of these disorders. In the following case, we present a 60-year-old Caucasian female with no prior documented autoimmune history who developed a blistering rash four days after receiving Moderna’s messenger ribonucleic acid vaccine. Initial laboratory and histopathology findings revealed elevated inflammatory markers and interface dermatitis. Over the course of several weeks, her rash progressed to bleeding and desquamation that covered approximately 80% body surface area. Further workup indicated positive ANA antibody and SS-A/Ro antibody leading to the diagnosis of subacute cutaneous lupus erythematosus (SCLE). She was treated with systems and topical steroids, as well as hydroxychloroquine. Six months post-diagnosis revealed marked improvement of her skin findings. Given the onset of her symptoms in relation to vaccine administration, it is suspected that Moderna’s vaccine may be associated with autoimmune disease onset.