AAV Assembled Capsids Are Produced in Cells Blocked from Cell Cycle Progression.

20250 citationsJournal Articlegold Open Access

Authors

Alaka Mullick · National Research Council Canada

Audrey Morasse · National Research Council Canada

Mélanie Leclerc · National Research Council Canada

Ziying Liu · National Digital Research Centre

Qing Yan Liu · National Research Council Canada

Sonia Leclerc · National Research Council Canada

Milica Momcilovic

Abstract

Adeno-associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 10 11and 10 15 viral genomes (v

Topics & Keywords

Virus-based gene therapy research RNA Interference and Gene Delivery Viral Infectious Diseases and Gene Expression in Insects

UN Sustainable Development Goals

Zero hunger

Publication Details

DOI: 10.22541/au.175593247.76283357/v1

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