Comparative Antitumor Efficacy and Toxicity Profile of SCC5, An Ag(I) <i>N</i>-Heterocyclic Carbene Complex, Relative to Platinum-based Chemotherapeutics

SCC5 maintains broad-spectrum antiproliferative activity with markedly improved <i>in vivo</i> tolerability compared to platinum drugs. These findings support continued preclinical development of SCC5 as a novel silver-based chemotherapeutic.