Identification of tear lipid biomarkers in women with dry eye disease and the impact of intense pulsed light therapy: a case-control study

Dry-eye subtypes appear to possess discrete lipidomic signatures; consequently, the lipid panel identified here could serve as a set of potential therapeutic targets. The dissociation between clinical improvement and lipidomic stability after IPL indicates that the therapy may benefit the ocular surface through mechanisms other than large-scale remodelling of the tear-film lipid layer, highlighting the need to explore complementary therapeutic pathways.