The tryptophan–serotonin axis in albinism: an interesting lead?

20250 citationsJournal Article

Authors

Benoît Gendrot · Centre National de la Recherche Scientifique

Marion Falabrègue · Centre National de la Recherche Scientifique

Camille Huet · Inserm

S. Matar · Centre National de la Recherche Scientifique

Bénédicte Oulès · Centre National de la Recherche Scientifique

Benoı̂t Arveiler · Inserm

Vincent Michaud

Abstract

Serotonin and other tryptophan-derived metabolites are altered in patients with albinism, with a distinct shift towards the serotonin pathway and impaired serotonin degradation. These metabolic disturbances suggest a potential link between tryptophan metabolism and pigmentation defects. Tryptophan profiling may offer novel diagnostic or therapeutic avenues for albinism.

Topics & Keywords

melanin and skin pigmentation Dye analysis and toxicity Biochemical Analysis and Sensing Techniques

Publication Details

Published in: British Journal of Dermatology

Volume 193, Issue 6, pp. 1251-1253

DOI: 10.1093/bjd/ljaf333

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The tryptophan–serotonin axis in albinism: an interesting lead?

Authors

Abstract

Topics & Keywords

Publication Details