Ontogenetic stage and type of donor cells shape extracellular vesicles’ therapeutic potential for osteoarthritis

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Authors

K. V. Tarasova · University of Veterinary Medicine Vienna

Maria Belen Arteaga · University of Veterinary Medicine Vienna

Angkana Kidtiwong · University of Veterinary Medicine Vienna

Harini Nivarthi · University of Veterinary Medicine Vienna

Johanna Gamauf · Evercyte (Austria)

Giovanni Corso · Evercyte (Austria)

Salih Sinan Gültekin

Abstract

The ontogenetic stage of donor cells plays a crucial role in EV's therapeutic efficacy, with fetal-derived EVs demonstrating superior outcomes compared to perinatal-derived EVs. The distinct effects of fCC-EVs and fMSC-EVs suggest that a combinatorial approach using both EV types could optimize therapeutic outcomes.

Topics & Keywords

Extracellular vesicles in disease Osteoarthritis Treatment and Mechanisms MicroRNA in disease regulation

Publication Details

Published in: Stem Cell Research & Therapy

Volume 16, Issue 1, pp. 478-478

DOI: 10.1186/s13287-025-04585-y

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Ontogenetic stage and type of donor cells shape extracellular vesicles’ therapeutic potential for osteoarthritis

Authors

Abstract

Topics & Keywords

Publication Details