Effects of combination therapy with SGLT2 inhibitors and GLP-1 receptor agonists on CRT response and clinical outcomes in in type 2 diabetes mellitus patients receiving chronic anti-diabetic medications: A multicenter observational study

20255 citationsJournal Articlehybrid Open Access

Authors

Celestino Sardu

Ludovica Vittoria Marfella · University of Campania "Luigi Vanvitelli"

Luca Rinaldi · University of Campania "Luigi Vanvitelli"

Ferdinando Carlo Sasso

Domenico Cozzolino · University of Campania "Luigi Vanvitelli"

Francesco Nappo · University of Campania "Luigi Vanvitelli"

Carmine Sellitto · University of Campania "Luigi Vanvitelli"

Abstract

In T2DM patients receiving CRTd, combination therapy with GLP-1RAs/SGLT2i was associated with improvements in cardiac function and clinical outcomes compared to monotherapy. GLP-1RAs/SGLT2i could optimize CRT responsiveness and reduce HF-hospitalizations in T2DM patients.

Topics & Keywords

Diabetes Treatment and Management Parkinson's Disease Mechanisms and Treatments Pharmacology and Obesity Treatment

Publication Details

Published in: Diabetes Research and Clinical Practice

Volume 228, pp. 112452-112452

DOI: 10.1016/j.diabres.2025.112452

Field-Weighted Citation Impact: 6.80

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Effects of combination therapy with SGLT2 inhibitors and GLP-1 receptor agonists on CRT response and clinical outcomes in in type 2 diabetes mellitus patients receiving chronic anti-diabetic medications: A multicenter observational study

Authors

Abstract

Topics & Keywords

Publication Details