Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease

20256 citationsJournal Articlehybrid Open Access

Authors

Moritz von Scheidt · Deutsches Herzzentrum der Charité

Shaunak Adkar · Stanford Medicine

Johannes Krefting · Deutsches Herzzentrum der Charité

Gregor Hoermann · Munich Leukemia Laboratory (Germany)

Manja Meggendorfer · Munich Leukemia Laboratory (Germany)

Sabine Bauer · Deutsches Herzzentrum der Charité

Shaneice Mitchell

Abstract

Clonal haematopoiesis of indeterminate potential is a predictor of mortality in CAD patients. TET2 mutations promote a pro-atherogenic macrophage phenotype via LDLR up-regulation and inflammatory activation, linking epigenetic dysregulation to adverse outcomes in CAD.

Topics & Keywords

Acute Myeloid Leukemia Research Myeloproliferative Neoplasms: Diagnosis and Treatment Kruppel-like factors research

Publication Details

Published in: European Heart Journal

Volume 47, Issue 4, pp. 453-469

DOI: 10.1093/eurheartj/ehaf602

Field-Weighted Citation Impact: 10.63

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Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease

Authors

Abstract

Topics & Keywords

Publication Details