Cumulative burden of estimated glomerular filtration rate and the risk of intracranial atherosclerosis: a prospective cohort study

In this cohort study, single-time-point eGFR, cumulative eGFR burden, eGFR slope, and exposure duration of reduced kidney function were all associated with increased risk of ICAS. Notably, cumulative eGFR burden, which captures both the duration and magnitude of kidney function decline, demonstrated superior predictive value compared with single-time-point eGFR for identifying individuals at risk of ICAS.