DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function

20254 citationsJournal Articlegreen Open Access

Authors

Omar Brito‐Estrada · Cincinnati Children's Hospital Medical Center

Yasuhide Kuwabara · Cincinnati Children's Hospital Medical Center

Aaron M. Gibson · Cincinnati Children's Hospital Medical Center

Keira R. Hassel · Cincinnati Children's Hospital Medical Center

Michael L. Kamradt · Cincinnati Children's Hospital Medical Center

Joseph Verry · Cincinnati Children's Hospital Medical Center

Abstract

DWORF overexpression enhances SR Ca<sup>2+</sup> dynamics, improves mitochondrial energetics, and attenuates pathological remodeling and heart failure progression in response to pressure overload. These findings support DWORF as a promising therapeutic target for heart failure.

Topics & Keywords

Mitochondrial Function and Pathology Cardiomyopathy and Myosin Studies Cardiovascular Function and Risk Factors

Publication Details

Published in: Circulation Research

Volume 137, Issue 8, pp. 1072-1088

DOI: 10.1161/circresaha.125.326550

Field-Weighted Citation Impact: 3.23

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DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function

Authors

Abstract

Topics & Keywords

Publication Details