Utility of [99mTc]Tc-tilmanocept, an immunosuppressive macrophage functional imaging agent in melanoma patients receiving checkpoint inhibitor treatment: a feasibility study

These preliminary pilot data provide the first-in-human proof of concept that CD206-based functional imaging showed measurable signal in tumour lesions in patients with advanced melanoma. If validated it might be useful in reflecting tumour immune status, hence help predicting tumour response to ICI.