Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma

20257 citationsJournal Articlehybrid Open Access

Authors

Imran Noorani · The Francis Crick Institute

Magnus Haughey · Queen Mary University of London

Jens Luebeck · University of California San Diego

Andrew Rowan · The Francis Crick Institute

Eva Grönroos · The Francis Crick Institute

Francesco Terenzi · Queen Mary University of London

Ivy Tsz-Lo Wong

Abstract

We study spatial patterns of ecDNA-amplified oncogenes and their evolutionary properties in human GBM, revealing an ecDNA landscape and ecDNA oncogene-specific evolutionary histories. ecDNA accumulation can precede clonal expansion, facilitating the emergence of EGFR oncogenic variants, reframing our interpretation of genomic data in a large subset of GBMs. See related commentary by Korsah et al., p. 1979.

Topics & Keywords

Cancer Genomics and Diagnostics Mathematical Biology Tumor Growth Glioma Diagnosis and Treatment

Publication Details

Published in: Cancer Discovery

Volume 15, Issue 10, pp. 2078-2095

DOI: 10.1158/2159-8290.cd-24-1555

Field-Weighted Citation Impact: 6.56

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Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma

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Abstract

Topics & Keywords

Publication Details