Multiomics Comparison of Proline‐Rich Peptide‐Enhanced Hyaluronic Acid Gels Versus Conventional Regenerative Materials: An Early Wound‐Healing Model

HA + P6 suppressed TNF-α and trypsin signalling while boosting M2-linked markers and proresolution proteins to the same extent as EMD, whereas plain HA did not. Thus, adding a short proline-rich peptide confers EMD-like early immunomodulation on a fully synthetic HA carrier. These observations, although limited to 6-day soft tissue healing, warrant longer studies in true periodontal regeneration models.