Increasing Acute Coronary Syndrome Mortality in Cirrhosis After a Period of Decline: A National Analysis of Temporal and Demographic Disparities

After years of decline, cirrhosis-associated ACS mortality has risen since 2014, with persistent disparities by sex, race/ethnicity, and rurality. These data support integrated cardio-hepatic pathways, targeted outreach to rural and historically underserved groups, and system-level quality improvement focused on time-sensitive ACS care in cirrhosis.