Inflammatory Myofibroblastic Tumor of the Tongue: A Rare Case in a Pediatric Patient

Inflammatory myofibroblastic tumors (IMTs) are rare neoplasms with intermediate biological potential, most often found in the abdominal cavity of children and young adults. Oral IMTs are extremely rare, presenting diagnostic challenges due to non-specific clinical features and a wide range of differential diagnoses. A 13-year-old female presented with an asymptomatic nodule on the dorsal tongue. Surgical excision was performed. Histopathological analysis, immunohistochemistry, and in situ hybridization identified spindle-shaped myofibroblastic cells, an inflammatory infiltrate, low proliferative activity (Ki-67), and an <i>ALK</i> gene rearrangement. These findings confirmed the diagnosis of oral IMT with a favorable prognosis. The surgical excision was complete. This case highlights the diagnostic complexity of oral IMTs and underscores the importance of histopathological and genetic analysis in establishing prognosis and identifying potential therapeutic targets.