Effects of hypoxia/hyperoxia exposure on immune function – results from a spacecraft-relevant hypobaric chamber study

These data indicate that, similar to living at high altitude, altered atmosphere exposure in a pressurized vehicle environment may dysregulate human immunity which may be exacerbated by EVAs. The additive effects of hypoxia, in concert with other spaceflight mission variables, on clinical risks for astronauts must be better characterized to enable future exploration class space missions.