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ABSTRACT The burden of dermatologic conditions is increasing worldwide and this rise is closely related to the interplay between epidemiologic trends and etiologic influences. The global population is experiencing an unprecedented increase in the proportion of older people. An aging population may be more susceptible to the effects of pollution and lifestyle‐induced skin changes due to age‐related declines in skin barrier function. Climate change alters the onset and progression of skin conditions through factors such as sunlight exposure, temperature, humidity, and extreme weather. In general, their effects have been associated with an increased incidence of various skin conditions. Environmental pollution, occupational and lifestyle factors not only exacerbate existing skin conditions but also contribute to the development of new dermatologic diseases. Urbanisation leads to increased exposure to pollutants that can induce oxidative stress and inflammatory responses in the skin, contributing to diseases such as atopic dermatitis and psoriasis. Lifestyle factors such as diet, stress, sleep patterns and skin care affect the skin's physiological processes, microbiome and immune response, influencing the onset and progression of various skin conditions. Advances in medical treatments, while improving disease outcomes and prolonging lifespan, are creating new dermatologic challenges that are exacerbated in vulnerable populations. As complexity and prevalence of skin conditions increase due to the intricate interactions of epidemiologic and etiologic factors, dermatologists and healthcare providers must rise to the challenge with understanding and innovation. This special issue will provide a dive deep into transformative strategies and groundbreaking paradigms that are reshaping the future of dermatological practice.