Hi-C Technology Reveals Actionable Gene Fusions and Rearrangements in Diffuse Large B-Cell Lymphoma Unidentified by Conventional FISH

20250 citationsJournal Articlegold Open Access

Authors

Sichen Liang · Johns Hopkins University

Candice Ament · Johns Hopkins Medicine

Melanie Klausner · Johns Hopkins Medicine

Victoria Stinnett · Johns Hopkins Medicine

Laura Morsberger · Johns Hopkins Medicine

Jen Ghabrial · Johns Hopkins Medicine

William Middlezong ·

Abstract

The Hi-C-based lymphoma assay offers a transformative diagnostic tool, overcoming FISH limitations by providing unbiased, high-resolution detection of structural variations. This approach enhances diagnostic accuracy and supports personalized therapeutic strategies in lymphoma management, warranting further validation for clinical adoption.

Topics & Keywords

Lymphoma Diagnosis and Treatment Chronic Lymphocytic Leukemia Research Cancer Genomics and Diagnostics

Publication Details

Published in: Genes

Volume 16, Issue 9, pp. 1093-1093

DOI: 10.3390/genes16091093

Field-Weighted Citation Impact: 0.00

Command Palette

Hi-C Technology Reveals Actionable Gene Fusions and Rearrangements in Diffuse Large B-Cell Lymphoma Unidentified by Conventional FISH

Authors

Abstract

Topics & Keywords

Publication Details