Germline whole-exome sequencing reveals <i>FOXP3</i>-related gene variants conferring urinary cancer susceptibility and associated with immune escape

Germline variants in a set of <i>FOXP3</i>-related genes confer inherent susceptibility to UTC and contribute to resistance against ICI. The immune-evading trait resulting from these variants and the downregulation of <i>FOXP3</i> expression introduce a novel avenue for personalized medicine through germline and tumor sequencing.