Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i> -Mutant Lung Cancer

UXS1 loss in KEAP1-mutant cells causes pyrimidine nucleotide depletion, DNA replication stress induction, and ultimately cell-cycle exit that results in tumor stasis, highlighting UXS1 as a potential therapeutic target in KEAP1-mutant tumors. See related commentary by Yasseen and DeNicola, p. 4582.