Distinct Pathogenic Mechanisms of Neurodegeneration in Pachychoroid Pigment Epitheliopathy Versus Intermediate Age-Related Macular Degeneration

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Authors

Pasquale Viggiano · El.En. Group (Italy)

Lorenzo Accurso Tagano · University of Bari Aldo Moro

Roberta Binetti · University of Bari Aldo Moro

Silvana De Leonardis · University of Bari Aldo Moro

Massimo Carella · University of Bari Aldo Moro

Giulia Ribezzi · University of Bari Aldo Moro

Alba Chiara Termite

Abstract

Two distinct pathways cause neurodegeneration: compressive (PPE: choroidal thickening → choriocapillaris compression → neurodegeneration) and ischemic (AMD: choroidal thinning → hypoperfusion → neurodegeneration).

Topics & Keywords

Retinal Diseases and Treatments Glaucoma and retinal disorders Retinal Imaging and Analysis

Publication Details

Published in: Ophthalmology and Therapy

Volume 14, Issue 11, pp. 2905-2918

DOI: 10.1007/s40123-025-01246-4

Field-Weighted Citation Impact: 3.42

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Distinct Pathogenic Mechanisms of Neurodegeneration in Pachychoroid Pigment Epitheliopathy Versus Intermediate Age-Related Macular Degeneration

Authors

Abstract

Topics & Keywords

Publication Details