Gain-of-Function Variant in <i>STAT3</i> and Retinal Macular Edema: Insights into the IL-6 R/JAK/ <i>STAT3</i> Pathway in Retinal Pigment Epithelium

The pathogenic STAT3 p.L387R GOF variant enhances inflammatory cytokine production in human primary RPE cells, potentially exacerbating retinal vascular leakage and macular edema. These effects can be mitigated by JAK1/2 inhibition, highlighting a promising therapeutic strategy for retinal inflammation and associated edema.