Subunit-Specific Immunodominance in Clinically Distinct Populations With AChR+ Myasthenia Gravis

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Authors

Kfir Oved · Pluristem Therapeutics (Israel)

Galit Denkberg · Pluristem Therapeutics (Israel)

Lena Pinzur · Pluristem Therapeutics (Israel)

Elisabeth Chroni · University of Patras

Vasiliki Zouvelou · Eginition Hospital

Inbar Arman · Pluristem Therapeutics (Israel)

Roei David Mazor

Abstract

Two distinct MG endotypes emerge based on sex, age, thymic involvement, autoantibody titer, and immunoglobulin AChR subunit immunodominance-suggesting different underlying etiologies with potential implications for sex-dependent precision medicine, women's health, and the development of new therapeutic modalities for MG.

Topics & Keywords

Myasthenia Gravis and Thymoma Cancer Treatment and Pharmacology

Publication Details

Published in: Neurology

Volume 105, Issue 8, pp. e214150-e214150

DOI: 10.1212/wnl.0000000000214150

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Subunit-Specific Immunodominance in Clinically Distinct Populations With AChR+ Myasthenia Gravis

Authors

Abstract

Topics & Keywords

Publication Details