Pressure-adjusted static compression: aerobic metabolism and microvascular perfusion in the context of chemotherapy-induced neuropathy

Reduction of oxygen demand represents an important mechanism in interventions targeting prevention of CIPN. PSC, comparable to cryoapplication and IPC attenuates energy metabolism and enhances tissue oxygenation. PSC's impact on the combination of vascular and energy metabolism suggests its potential to alleviate CIPN burden. These findings support PSC's role in reducing acral CIPN through distinct mechanisms.